In a game belonging in a different competition, AC Milan come to Old Trafford with a decimated squad and will be desperate to keep the tie alive by the time they travel back to Italy.
Manchester United are favourites and for good reason – the Italian clubs season has derailed in 2021 and their impressive form in the previous calendar year has worn off.
The visitors are without their influental attacking trio of Ibrahimovic, Rebic & Calhanoglu whilst Manchester United will have to do without both Cavani and Rashford.
Dean Henderson will continue between the sticks for United as he searches for a fifth straight clean sheet. Lindelöf is likely to sit this one out as he is still nursing a back problem.
Both teams will be expected to field a full-strength team in their attempts to secure a place in the quarter-finals of the Europa League. Semi-finalists last year, Solskjær and his team will be desperate to get their hands on a first trophy under his stewardship.
Manchester United (4-2-3-1): Henderson; Wan-Bissaka, Bailly, Maguire, Telles; McTominay, Fred; Greenwood, Fernandes, James; Martial
AC Milan (4-2-3-1): Donnarumma; Calabria, Kjær, Tomori, Dalot; Kessie, Tonali; Castillejo, Saelemaekers, Diaz; Leao